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Case 3: A 43-year-old man with type 2 diabetes initiated tirzepatide at 2.5 mg and developed bilateral neck and shoulder pain accompanied by morning headaches

A total of 706 overweight or obese participants were randomized to once-weekly cagrilintide (0.34.5 mg), once-daily liraglutide 3.0 mg, or placebo for 26 weeks, followed by a 6-week off-treatment period

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Long-Term Safety Gaps Without human trials, its impossible to rule out risks like abnormal cell growth, cancer promotion, or autoimmune flare-ups

The GLP-1 receptor agonist group was also less likely to have an adverse safety outcome than those receiving a DPP-IV inhibitor (HR = 0.9