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GLP-1 (glucagon-like peptide-1) is a naturally occurring incretin hormone secreted by enteroendocrine L-cells in the small intestine in response to food intake, where it signals satiety to the brain through hypothalamic receptor binding, slows gastric emptying to prolong the feeling of fullness, and modulates the release of insulin and glucagon in a glucose-dependent manner that helps stabilize post-meal blood sugar without the hypoglycemia risk associated with older drug classes
Arch Pharm Res 35(1):145154
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2025 Jun 3;97(21):11099-11109
Its C16 fatty acid attachment mechanism provides 55% bioavailability with extensive albumin binding exceeding 98% [25]
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