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Functional and Structural Changes: MRI and CT Scans : Imaging for detailed evaluation of ocular and orbital involvement in severe cases of thyroid eye disease [43-45]

The trial ended at 48 weeks with weight still declining, suggesting results may continue beyond one year

If you are still losing weight and appetite is controlled, you may not need to increase

In terms of body weight, oral-semaglutide treatment led to mean reductions of -2.5 kg (treatment-policy estimand) and -2.7 kg (trial-product estimand)

PMID: 22817979

And in many of the warning letters issued this year, the underlying issues werent exotic they were preventable: incomplete documentation, insufficient controls, unvetted suppliers, gaps in clinical oversight, or programs that had drifted away from written procedures