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IV supplementation bypasses natural absorption controls
Site Rotation Protocol Rotating injection sites prevents lipohypertrophy (fatty lumps under skin), reduces scar tissue formation, and maintains consistent absorption
They do not demonstrate biological activity, safety, or effectiveness
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Some providers even use topical anesthetic to make it more comfortable
[172] [173] A 2026 systematic review on ADHD medication tolerance found evidence of tolerance developing to some affective state effects of amphetamine (e.g., positive mood and drug liking) within two weeks of daily use, but little to no evidence of long-term tolerance to its therapeutic or cardiovascular effects
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