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Because weight loss with tirzepatide is expected to reduce both fat and skeletal muscle mass, creatinine could be less accurate as a measure of kidney function

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Protocols begin at 0.25 mg weekly and are titrated upward over approximately 16-20 weeks to a typical maintenance dose of 1.0 to 2.4 mg weekly, based on individual tolerability and provider guidance

Meaningful drug activity persists for 2 to 3 weeks after the last injection