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Indeed, research attention in the last decade has focused significantly on antioxidants targeting the mitochondria, and it appears that the focus is shifting from more traditional antioxidants (see Figure 2)

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Female sex hormones modulate the function of LPS-treated macrophages

While not everyone with IgG4-RD experiences headaches, the disease can impact areas that lead to persistent or severe headaches, such as: The meninges: These protective brain layers can thicken and become inflamed (hypertrophic pachymeningitis), resulting in ongoing, sometimes debilitating headaches