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Molecules 27 (8), 2446

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328,331,332 The Chinese medicine monomer ferulic acid improves cognitive dysfunction and reduces hippocampal neuron damage by activating SIRT1/Nrf2-mediated ferroptosis

Intravenous administration allows glutathione to bypass the digestive system, leading to higher bioavailability and more effective increases in glutathione levels compared to oral supplements

Limited human contexts Heterogeneous formulations, endpoints, and study designs

Metallothionein and metal binding A second line of defense is metallothionein, a family of small, metal-hungry proteins encoded by genes such as MT1A and MT2A