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Interestingly, recent studies have proposed that DNA methylation can lead to the exclusion of a histone variant (H2A.Z), preferentially located at active gene promoter 36,37

It is studied in laboratory research for its role in fat oxidation, lipolysis, adipose tissue metabolism, lipogenesis inhibition, and cartilage repair pathway biology without the IGF-1 stimulation, insulin resistance, or receptor-mediated proliferative effects associated with full-length hGH

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