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More serious but rare complications include pancreatitis, gallbladder disease, and hypoglycaemia (particularly in those taking other glucose-lowering medications)

Both have changed what is possible with non-surgical weight loss, and there is now head-to-head clinical data showing how they stack up against each other

E., Nigar, S., Olivo, R., & Gaduputi, V

7.4 Intestines While semaglutides effects on the intestines are predominantly associated with gastrointestinal side effects, its impact on gut health and function warrants attention

Severe Gastrointestinal Adverse Reactions Inform patients of the potential risk of severe gastrointestinal adverse reactions

June 2026