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J Clin Hepatol

Most patients find that gastrointestinal side effects improve significantly after the first 24 weeks of treatment, and the benefits of the medication become more apparent as tolerance develops

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For example, a functional score change in a rodent injury model may reflect altered edema, preserved microvascular flow, changed inflammatory response, neurotransmitter modulation, or general systemic stabilization after experimental injury

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Whilst back pain is not listed as a common side effect in the Summary of Product Characteristics for these medications, some patients report musculoskeletal discomfort during treatment