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The coordinated nature of these pathway disruptions is particularly significant, as CSCs often demonstrate remarkable plasticity and can maintain their stem-like properties through compensatory activation of alternative signaling routes when individual pathways are targeted in isolation

Semaglutide and tirzepatide carry a boxed warning for thyroid C-cell tumors observed in animal studies, and the medications are contraindicated for anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

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