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[38] In addition to increasing production and secretion GHRH also affects sleep patterns by increasing the amount of slow wave sleep (SWS) while augmenting sleep-related GH secretion and reducing cortisol secretion
Unpublished studies in our laboratory have suggested that some amounts of MDM2, by inducing ubiquitination, are important for internalisation and activation of the IGF-1R
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However, current evidence does not support this concern in practice
