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This activation triggers mitochondrial depolarization by disrupting the mitochondrial membrane potential, leading to cytochrome c release and subsequent activation of caspase-9 and caspase-3, the executioners of apoptosis [14]
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In your pancreas, it increases insulin production and regulates blood sugar levels
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In the databases of adverse drug events in multiple countries, the number of reports of mood changes, suicidal ideation and depression related to GLP-1RA has been on the rise, prompting regulatory authorities to request further monitoring [13, 15, 26, 27]
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