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doi:10.1016/j.autrev.2011.01.009
However, groups switched from WD to LD (WD/LD-V, WD/LD-T) tended to show greater alpha diversity compared to the control groups (WD/WD-V and LD/LD-V), which was not surprising since these animals experienced the most diet transitions with variable nutrient resources during their lifetime
That said, the compound has not been through full Phase III trials or FDA drug approval
The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake
Combined use of both compounds is entirely unstudied in humans and carries unpredictable metabolic and cardiovascular risks
