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For example, the RNA sequencing analysis on isolated enteroendocrine cells from obese individuals with or without T2DM revealed decreased expression of the PCSK1 gene in the jejunal epithelium, contributing to the biosynthesis of GLP-1 [32]

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Secondary outcomes included nonfatal MI, nonfatal stroke, HHF and renal composite outcome, defined in most trials as a composite of progression to end-stage renal disease or a sustained decrease of at least 40% in estimated glomerular filtration rate (eGFR)