However, a proteasome-independent mechanism might also contribute to CIPN
This process requires a lot of energy and, as a byproduct, creates its own free radicals
Buffer selection influences stability profoundly
Similar trends were observed in a mouse model of pancreatic ductal adenocarcinoma (PDAC) ( LSL-Kras G12D/+ Trp53 f/f Pdx1 cre (KP / C) mice 28 ) and in humans with renal cell carcinoma 29 (Extended Data Fig
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Intravenous or subcutaneous fluid therapy is crucial, to keep the pancreas well perfused with blood and to restore normal fluid and electrolyte balance