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Nausea, GI discomfort, constipation, fatigue, and other symptoms can occur, especially when starting treatment or adjusting the dose

They lack hair or down, are not able to obtain food

This happens due to the production of trimethylamine during metabolism

Those with inflammatory bowel disease, including Crohn's disease or ulcerative colitis, may experience symptom exacerbation, though evidence remains mixed regarding causation versus coincidence

Wong BW, Marsch E, Treps L, Baes M, Carmeliet P

5.1.2 Effects on pancreatic -cell glucagon release In addition to their insulinotropic effects on -cells, both GIP and GLP-1 play a role in regulating glucagon secretion of pancreatic -cells, with GIP increasing and GLP-1 suppressing glucagon secretion, both in a glucose-dependent manner