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If they do not, do not invent a priming step based on a different medication or a social media video
Epac, exchange protein directly activated by cAMP
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Eur J Med Res 30(1):260 Rooks D, Praestgaard J, Hariry S, Laurent D, Petricoul O, Perry RG et al (2017) Treatment of sarcopenia with bimagrumab: results from a phase II, Randomized, Controlled, Proof-of-Concept study
Red arrow indicates significant difference seen in first four weeks, while patients had only lost 2.7% of their body weight, suggesting effect is independent of weight loss
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