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Some individuals have genetic variants that enhance muscle protein synthesis, making creatine more effective

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Update to Management of Hyperglycemia in T2D: A Consensus Report by the ADA and the European Association for the Study of Diabetes The ADA and the European Association for the Study of Diabetes (EASD) also revised their joint consensus on the management of hyperglycemia in T2D in 2018

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This approach isolates which intervention contributes to benefits and side effects, enabling safer titration