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GSH can be oxidized to its dimeric form, GSSG, in which way to scavenge reactive oxygen species and free radicals, protecting cells from oxidative stress and toxins 4

In this oral formula, semaglutide is non-covalently linked to sodium N-[8-(2-hydroxybenzoyl) aminocaprylate] (SNAC), which shields the peptide from enzymatic and acidic degradation in the stomach (100)

N Engl J Med 387:205216

10.1038/s41574-023-00821-8 3 BeccutiG.BiolettoF.Parasiliti-CaprinoM.BensoA.GhigoE.CicolinA.et al (2024)

Research is necessary to explore any potential role of GLP-1 analogs in treating IBD, including Crohns disease, in the absence of metabolic comorbidities

Mor DE, Daniels MJ, Ischiropoulos H