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Finally, Fe 2+ is released from divalent metal transporter 1 (DMT1) mediated endosome into unstable iron pool in the cytoplasm [51]
HERMES editing with 20 ms editing pulses applied at 1.9 ppm and 4.56 ppm(Saleh, Wang, et al., 2020)
The mechanism involves stimulating over 300 different genes associated with tissue repair and remodeling, fibroblast activation and collagen synthesis, epidermal basal stem cell viability, an anti-inflammatory effect, an antioxidant effect and stimulation of microvascular growth
This phenomenon is associated with a delay in the resolution phase of the healing process because aberrant messages are sent to T- and B-lymphocytes and macrophages, thereby impairing re-epithelialization and remodeling (which is normally carried out by platelets, macrophages, epitheliocytes and fibroblasts and represents the final phase of healing-associated physiological inflammation)
