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Types Hemoglobin is made up of four protein chains: two alpha-globin chains, consisting of 4 genes (two from each parent), and two beta-globin chains, consisting of 2 genes (one from each parent)

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Studied in models involving ERR signaling, mitochondrial output, exercise-mimetic pathways, and metabolic adaptation

Preclinical studies likewise suggest a favorable safety profile [12, 13]

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