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Long-term safety data from human use is limited

Diabetes Care 47(10):17181730 Lundgren JR, Janus C, Jensen SBK, Juhl CR, Olsen LM, Christensen RM et al (2021) Healthy weight loss maintenance with Exercise, Liraglutide, or both combined

You can't study fat loss when the intervention makes subjects 30% hungrier

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Many individuals begin to notice changes in appetite and weight within a few weeks of starting treatment

Peri-tumoral HSC signaling and ECM remodeling is considered important mechanisms contributing to HCC progression by forming a prometastatic microenvironment facilitating cancer cell adhesion, growth and migration 66