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These interactions involve orexigenic hormones like ghrelin and anorexigenic hormones such as GLP-1, leptin, and peptide YY (PYY) (10)

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[17] [18] This rapid degradation necessitates the development of modified GLP-1 analogues or DPP-4 inhibitors to achieve sustained therapeutic effects

if you take it late, you might experience a return of hunger