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This particular systematic review and meta-analysis looked at the association between insomnia and the incidence of heart attack, also called myocardial infarction (MI)
Academic medical centers have also noted the lack of structured data at microdose levels
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It has a high affinity for copper ions (Cu), forming a stable and biologically active complex that enhances coppers bioavailability and intracellular activity
However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans
