A head-to-head clinical trial (SURMOUNT-5) published in The New England Journal of Medicine in 2025 also demonstrated the superiority of tirzepatide over semaglutide
Following Connecticuts drastic increase in utilization under their state employee health plan, in 2023 the state began requiring enrollees to enroll in a telehealth program that sought to encourage full-scale lifestyle changes and eventually reduce dependence on GLP-1s and similar medications
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Both therapies also aid in controlling obesity-related complications
However, when combined with insulin or sulfonylureas, hypoglycemia risk increases, and dose adjustments of these concomitant medications may be necessary
SLH reports support by grants from the National Institutes of Health and Office of Dietary Supplements (P20HL113452 and R01HL103866)
