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The fraction of protein binding is independent of drug concentration, over the clinically relevant concentration range, but decreases to ~99% in patients with renal disease

Retrieved from Cibralic, S., Pickup, W., Mendoza Diaz, A., et al

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In the 12 mg group, every participant lost at least 5 percent, 93 percent lost at least 10 percent, and 83 percent lost at least 15 percent

Terada T, Obi T, Bunai T, Matsudaira T, Yoshikawa E, Ando I, et al