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At doses of 5-10mg daily for 4-6 weeks, most women experience significant muscle preservation and enhanced fat loss with minimal risk of virilization

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Difficulty keeping medications down : If you are vomiting frequently, oral medications may not be absorbed effectively, and alternative routes of administration may be needed

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Milk thistle may also interact with the following medications, though the interactions are less concerning and only require monitoring after ingestion:2 Fosphenytoin-phenytoin Indinavir Losartan Metronidazole Sirolimus Tolbutamide Vitamin K antagonists On the brighter side, most adverse reactions to milk thistle are minor and brief