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CY-5, a novel GLP-1/GIP dual receptor agonist, was recently discovered by Liu et al., which showed efficacy in reducing serum lipids, LFTs, and biopsy-proven hepatic steatosis in an AMLN diet NAFLD mouse model [47]

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The 2-year limit exists because clinical trials hadnt extensively studied outcomes beyond this duration when NICE made its recommendation, and because of cost-effectiveness modelling

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CrossRef A prognostic signature of ferroptosis and lipid metabolism related genes predicts survival and immunotherapy response in hepatocellular carcinoma Hu Chen, Yan Kong, Qian Dong Discover Oncology .2026;[Epub] CrossRef Emerging importance of ALDH2 in liver diseases and its potential therapeutic role Sheng Wang, Shiqiang Xu, Guoqing Xia, Xinren Wang, Xiongwen Lv Biochemical Pharmacology .2026

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2007;71(Pt 6):705-712

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