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4 Challenges and future directions 4.1 Safety considerations The safety profile of dual or triple receptor agonists targeting GLP-1, GIP, and GCG receptors in the treatment of MASLD and related metabolic disorders warrants careful evaluation

No increased risks of hospitalization for diabetic ketoacidosis or severe hypoglycemia were observed

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However, factors like overall health, metabolism, and post-therapy care significantly influence the treatments effectiveness and outcome