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GLP-1 receptor activation exerts a chronotropic effect via the sinoatrial node

Participants were randomized to placebo or retatrutide at 1 mg, 4 mg (dose-escalation), 4 mg (no escalation), 8 mg (escalation), 8 mg (no escalation), or 12 mg (escalation) for 48 weeks, following a slow titration protocol

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Its defined half-life profile is valuable for time-course experiments examining receptor activation and desensitisation dynamics