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Any such combination requires baseline kidney function testing and regular monitoring

Furthermore, an interventional clinical trial revealed recently the amelioration of AAC was not followed by an increase or decrease in the sKlotho level in MHD patients with secondary hyperparathyroidism, which further challenged the clinical value of sKlotho in VC (Chou et al., 2019) The inconsistent studies were summarized and the average score was 6.6 stars, as shown in Table 4

LEADER trial: Cardiovascular outcomes with liraglutide JAMA Network Open (2022)

Rheumatology 61 , 407412 (2021)

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