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Further information is available via NHS medicines information pages and NICE guidance at nice.org.uk
The advisory committees recommendation does not mean the drugs have been approved by the FDA
Management: Start with lower doses and titrate slowly
Unexplained elevated B12 levels warrant medical investigation including liver function tests, renal function assessment, and full blood count
The exception is highly potent peptides (like semaglutide) where tiny doses of concentrated solution are intentional and where specialized fine-gauge syringes may be used
A high-dose B12 shot, which is given intramuscularly as prescribed by a doctor, can quickly resolve a deficiency by raising the level of vitamin B12 in the blood
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