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As introduced earlier, gastrointestinal (GI) side effects tend to happen most frequently when taking this medication

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However, berberine does not directly act on GLP-1 receptors

Patients with a documented history of suicidal ideation or suicide attempts prior to the index date were excluded to minimize potential confounding, because the presence of prior suicidality can indicate a distinct clinical pathway and risk profile that might obscure new-onset events

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