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In another small study in healthy men with cardiovascular risk factors, those with abnormal reactive hyperemia index (RHI) which measures peripheral endothelial function and stiffness, experienced a significant reduction in arterial stiffness after taking sublingual glutathione

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Among elderly individuals, vitamin B 12 deficiency is more common, primarily because of impaired intestinal absorption that can result in marginal to severe vitamin B 12 deficiency in this population