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Then comes the relentless, sprawling expense of marketingboth to consumers and to doctors

and Eli Lilly, the maker of tirzepatide, the active ingredient in Zepbound, warn about medications claiming to be the compounded versions of brand-name GLP-1 weight-loss drugs

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Alternatively, if one system is strained, there is a cascade that affects all systems in the body

This dual-acting drug targets GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, offering a potentially more effective approach to weight loss

The people who switched to placebo regained 14% of their starting weight, retaining only about a third of the weight loss theyd initially achieved