GLP-1RAs can suppress foam cell formation by activating GLP-1R signaling induced autophagy [134], reducing ACAT1 expression/activity [93], as well as inhibiting the PKA/CD36 pathway to inhibit ox-LDL uptake [135]
These medications are delivered subcutaneously, which means they work best when injected into fatty tissue
Lower pricing could allow clinicians to initiate GLP-1 treatment earlier for patients who previously could not afford these medications
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