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CB-839 is the most advanced GLS1 inhibitor currently in clinical practice and has been shown to effectively inhibit tumor proliferation ( L-asparaginase can deplete plasma Gln and is widely utilized as an adjuvant therapy in lymphoma ( In vitro experiments on lung cancer cells revealed that L-asparaginase treatment significantly induced autophagy activation in A549 cells, leading to their apoptosis ( 5 Discussion Metabolic reprogramming is essential for the advancement of tumors and has become a central topic in cancer research lately ( While substantial progress has been accomplished in the study of tumor Gln metabolism in recent years, several key issues remain to be addressed (1)
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High standardized uptake values (SUVs) on PET imaging can help differentiate MPNST from benign schwannomas or neurofibromas, particularly in NF1 patients (Ferner et al., 2008)
Feb.-April 2022 and 2023
However, other causes are identified, including an increase in colonic epithelial apoptosis Endoscopically, the mucosa may show a brownish discoloration in a moire pattern
Int J Gynecol Pathol 36:517522
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