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Imitating GIP can enhance the release of insulin, improve the metabolism of fat and boost fullness, typically wielding slightly higher weight loss results of an average of 15 percent body weight lost compared to Mounjaro's 20 percent average

Conversely, some find the daily lower spike of the drug easier to manage than the weekly peak of the injection

The cohort included 8942 patients who added a GLP-1 receptor agonist to their SGLT-2 inhibitor treatment, who were matched to an equal number of patients using SGLT-2 inhibitors only (fig 3)

Notably, treatment with S-1 increased tumor-infiltrating effector T cells and dendritic cells, thereby fostering an anti-tumor immune response

The trial data are available at PubMed (PMID: 37530551), providing peer-reviewed evidence for the retatrutide weight-loss results

It comes as a pen device that patients inject under the skin once a week