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But a side effect quickly stole the spotlight: People taking GLP-1s started losing significant amounts of weight
Future studies should further investigate the critical role of the lysosomeautophagy axis in the pathophysiology of AP, with the aim of establishing a theoretical foundation for the development of targeted therapeutic interventions
2018 May;22(2):325-346
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In the larger SELECT trial in 2023, patients with heart failure, atherosclerotic disease, and overweight or obesity, treated with semaglutide 2.4 mg showed reduction in major adverse cardiac events (MACE) and heart failure end points regardless of heart failure subgroup being HFrEF or HFpEF [56,57,58]
The obtained results confirm the findings of RCTs, which showed a better effect of semaglutide on weight loss and HbA1c level in real-world conditions
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