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In special life situations, such as during competitive sports, diets or during pregnancy and breastfeeding, there may also be an increased need for L-carnitine and thus a deficiency
The pharmacokinetic properties including intestinal permeability, first-pass metabolism, microbiota-mediated biotransformation, plasma half-life, and systemic availability is essential for translational relevance
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These pharmacologic doses support immune defense, collagen synthesis, oxidative stress reduction, and at very high levels may exert selective cytotoxic effects against abnormal cells