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Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up

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Pharmacological Management of Nonalcoholic Fatty Liver Disease

Their highly conserved regulatory, kinase, and association domains make isoform selectivity a key challenge, as each has distinct tissue-specific functions, and off-target inhibition may cause toxicity

They currently offer 5mg DSIP nasal spray bottles that are measured at 50mcg/spray