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It is not appropriate for everyone, and understanding who benefits most helps researchers make informed decisions about whether the added complexity and cost are justified
Clin Sci (London England: 1979) (2019) 133(3):40923
V.BelikovaT
Metformin activates the AMPK signaling pathway, which enhances mitochondrial function, limits mitochondrial ROS production, and promotes antioxidant defense through downstream stimulation of Nrf2-dependent cytoprotective genes
The authors suggest it may have future potential not only in skin and wound care, but also in supporting healthy aging, managing chronic inflammatory and degenerative conditions, and possibly as an adjunct approach in diseases such as COPD and cancer
During the 5-min exploration in the open-field arena, there were no significant differences in the mean speed ( P = 0.3225
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