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According to NICE guidance and MHRA safety information, healthcare professionals should maintain vigilance for rare but serious adverse effects including acute pancreatitis, gallbladder disease, and potential thyroid tumours (based on animal studies, though human risk remains uncertain)

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The first RCT to investigate the effect of liraglutide in patients with NAFLD was the LEAN study, in which 52 patients with NASH were randomized to either 48 weeks of treatment with liraglutide (1.8 mg/day) or placebo (66)

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Contrave is approved by the Food and Drug Administration (FDA) for weight loss in adults only