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It's a permanent loss of activity

As a transcription target of p53, the activity of spermidine/spermine N 1 -acetyltransferase 1 (SAT1), the rate-limiting enzyme in polyamine catabolism, induces lipid peroxidation and sensitizes cells to undergo ferroptosis and the deletion of SAT1 suppresses p53 and p53 3 KR -mediated ferroptosis

There were no significant differences among the three doses of lipoic acid, suggesting that 600 mg/day may be the maximum effective dose (55)

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These effects are usually mild and transient

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