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Early phase 2 clinical trial data also suggest a possible contribution to increased energy expenditure, though this effect has not yet been definitively confirmed as a major contributor to weight loss in humans and remains an area of ongoing investigation

Mazdutide led to mean weight reductions of 12.1% (4 mg) and 14.8% (6 mg) of body weight at week 48, compared with 0.5% in the placebo

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