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Clinical trials have shown that Tirzepatide leads to greater HbA1c and body weight reductions compared to semaglutide

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First, several of these compounds are promoted for their effects on blood vessel growth, and NPR reported FDA raised concerns about the potential to encourage cancer growth. If you have a cancer history, that is not a small footnote

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Furthermore, activin mediates FSH release from the pituitary and is necessary for childbirth 25 , and there is also a recent publication suggesting myostatin also regulates FSH levels in rodents 54