Suramin prevents the binding of IL-6 to its cell surface receptor subunits, as demonstrated by radioreceptor binding assay and affinity crosslinking experiments
Think of it as noise reduction
Diurnal variation of sweet taste recognition thresholds is absent in overweight and obese humans
Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW
The appetite-suppressing effects might reduce binge eating but could also reinforce the food restriction that typically precedes binges and worsen the cycle overall ( Schaefer et al., Psychiatric Clinics of North America, 2026 )
This approach allows assessment of individual response and minimizes the impact of any unexpected sensitivity