Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias
This mechanistic separation means direct drug-drug interactions are unlikely from a pharmacokinetic perspective
2 A separate 2-week RCT testing three GlyNAC dose levels in 114 healthy older adults found good tolerability but no significant improvement in the primary endpoint (GSH:GSSG ratio) in the full study population, highlighting that responses may depend on baseline oxidative stress levels and study duration
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