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PMID 22616870

Side effects are broadly similar, with tirzepatide more often linked to nausea and vomiting, and semaglutide more to constipation and reflux

Although GLP-1 class medications have been on the market for 2 decades now, rarer serious side effects are now being seen more simply due to recent increases in the number of people on these medications3

Diagnostic criteria Mild hyponatremia: 130135 mEq/L Moderate hyponatremia: 125129 mEq/L Severe hyponatremia: 295 mOsmol/kg H 2 O Causes Hyperglycemia IV mannitol IV radiocontrast use Isotonic hyponatremia [2] [5] Definition: : low measured serum Na + concentration and normal serum osmolality Serum osmolality: 280295 mOsmol/kg H 2 O Causes TURP syndrome [9] Pseudohyponatremia Asymptomatic laboratory artifact falsely indicating hyponatremia when sodium has not been reduced or diluted Due to very high amounts of protein or lipids in the plasma (e.g., hyperlipidemia, multiple myeloma), which then alter the plasma water concentration Clinical features may include: Isotonic hyponatremia should always be excluded as a cause of hyponatremia to avoid unnecessarily aggressive treatment

Eli Lilly is also selling the pill directly on its website, with cash pay prices of $149 to $349 a month, depending on the dose.